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Nutrient balance, movement, sleep, and stress all play a significant role in weight regulation, as they affect hunger hormones and prevent metabolic adaptation. Eating more nutritious foods and exercising can enhance the positive effects of Topamax and improve your overall well-being

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15 Both dysbiosis and impaired gut integrity have been strongly associated with the development of overweight, obesity and metabolic syndrome, and should be a key focus of therapeutic protocols either independent of or alongside GLP-1 agonist therapy in supporting weight management

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Hence, the low expression of GLP-1R mRNA in LA might explain why we failed to detect a PIE in the LA